CD105 expression in early erythroid precursors
نویسندگان
چکیده
منابع مشابه
Macrocytosis Resulting from Early Denucleation of Erythroid Precursors.
By SATIMARU SENO, MASANOBU MIYAHARA, HIKARU ASAKUBA, OSAMU Oc:HI, KENICHI MATSUOKA AND TAKENORI Toyu t M ACROCYTOSIS has long been recognized as a common occurrence during the development or recovery from acute anemia.1 It was ascribed to the appearance of large numbers of reticulocytes in the peripheral blood. Recently, Brecher and Stohlman demonstrated that the macrocytosis after administrati...
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Erythropoietin induces a dose-dependent increase in cytosolic calcium in human erythroblasts that is mediated by a voltage-independent Ca 2 1 channel. Inhibition of this response to erythropoietin by pertussis toxin suggests involvement of guanine nucleotide-binding regulatory proteins (G-proteins). The role of G-proteins in regulation of the erythropoietin-modulated Ca 2 1 channel was delineat...
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During ontogeny, the hematopoietic system is established from mesoderm-derived precursors; however, molecular events regulating the onset of hematopoiesis are not well characterized. Several members of the transforming growth factor beta (TGF-beta) superfamily have been implicated as playing a role during mesoderm specification and hematopoiesis. CD105 (endoglin) is an accessory receptor for me...
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This study examines published steady state cell kinetic (mitotic and DNA synthesis phase) data from the recognizable proliferating erythroid precursors in humans, rats, and guinea-pigs, and human neutrophilic precursors, for consistency with a continuous maturation-proliferation model of the cell cycle. We find that these data are completely consistent with the hypothesis that maturation betwee...
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Early erythroblasts from patients with refractory anemia (RA) and RA with ringed sideroblasts (RARS) show constitutive mitochondrial release of cytochrome c. Moreover, mature erythroblasts in RARS, but not in RA, display aberrant accumulation of mitochondrial ferritin (MtF). We analyzed cytochrome c release, MtF expression, and gene expression during erythroid differentiation in bone marrow cel...
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ژورنال
عنوان ژورنال: American Journal of Hematology
سال: 2017
ISSN: 0361-8609
DOI: 10.1002/ajh.24763